Austrian Breast & Colorectal Cancer Study Group

Science from the heart of Europe

The PAM50 Risk-of-Recurrence Score Predicts Risk for Late Distant Recurrence after Endocrine Therapy in Postmenopausal Women with Endocrine-Responsive Early Breast Cancer

Filipits M, Nielsen T, Rudas M, Greil R, Stöger H, Jakesz R, Bago-Horvath Z, Dietze O, Regitnig P, Gruber-Rossipal C, Müller-Holzner E, Singer C, Mlineritsch B, Dubsky P, Bauernhofer T, Hubalek M, Knauer M, Trapl H, Fesl C, Schaper C, Ferree S, Liu S, Cowens J, Gnant M, for the Austrian Breast and Colorectal Cancer Study Group

Clinical Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/24520097

Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial

Taieb J, Tabernero J, Mini E, Subtil F, Folprecht G, van Laethem J, Thaler J, Bridgewater J, Norgard Peterson L, Blons H, Collette L, van Cutsen E, Rougier P, Salazar R, Bedenne L, Emile J, Laurent-Puig P, Lepage C

The Lancet Oncology

https://www.ncbi.nlm.nih.gov/pubmed/24928083

Preoperative Treatment with Capecitabine, Cetuximab and Radiotherapy for Primary Locally Advenced Rectal Cancer – A Phase II Clinical Trial

Eisterer W, De Vries A, Öfner D, Rabl H, Koplmüller R, Greil R, Tschmelitsch J, Schmid R, Kapp K, Lukas P, Sedlmayer F, Höfler G, Gnant M, Thaler J

Anticancer Research – International Journal of Cancer Research and Treatment

https://www.ncbi.nlm.nih.gov/pubmed/25368289

Role of bisphosphonates in postmenopausal women with breast cancer

Gnant M

Cancer Treatment Reviews

https://www.ncbi.nlm.nih.gov/pubmed/23906846

Zoledronic acid combined with adjuvant endocrine therapy of tamoxifen versus anastrozol plus ovarian function suppression in premenopausal early breast cancer: final analysis of the Austrian Breast and Colorectal Cancer Study Group Trial 12

Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Knauer M, Moik M, Jakesz R, Seifert M, Taucher S, Bjelic-Radisic V, Balic M, Eidtmann H, Eiermann W, Steger G, Kwasny W, Dubsky P, Selim U, Fitzal F, Hochreiner G, Wette V, Sevelda P, Ploner F, Bartsch R, Fesl C, Greil R

Annals of Oncology 2015 Feb;26(2):313-20. Epub 2014 Nov 17.

https://www.ncbi.nlm.nih.gov/pubmed/25403582

Prediction of Late Distant Recurrence After 5 Years of Endocriner Treatment: A Combined Analysis of Patients From the Austrian Breast and Colorectal Cancer Study Group 8 and Arimidex, Tamoxifen Alone or in Combination Randomized Trials Using the PAM50 Risk of Recurrence Score

Sestak I, Cuzick J, Dowsett M, Lopez-Knowles E, Filipits M, Dubsky P, Cowens JW, Ferree S, Schaper C, Fesl C, Gnant M

Journal of Clinical Oncology 2015 March 10;33(8):916-922. Epub 2014 Oct 20.

https://www.ncbi.nlm.nih.gov/pubmed/25332252

The PAM50 Risk-of-Recurrence Score Predicts Risk for Late Distant Recurrence after Endocrine Therapy in Postmenopausal Women with Endocrine-Responsive Early Breast Cancer

Filipits M, Nielsen T, Rudas M, Greil R, Stöger H, Jakesz R, Bago-Horvath Z, Dietze O, Regitnig P, Gruber-Rossipal C, Müller-Holzner E, Singer C, Mlineritsch B, Dubsky P, Bauernhofer T, Hubalek M, Knauer M, Trapl H, Fesl C, Schaper C, Ferree S, Liu S, Cowens J, Gnant M, for the Austrian Breast and Colorectal Cancer Study Group

Published OnlineFirst February 11, 2014

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CYP2D6 Metabolism and Patient Outcome in the Austrian Breast and Colorectal Cancer Study Group Trial (ABCSG) 8

Goetz MP, Goetz MP, Suman VJ, Hoskin TL, Gnant M, Filipits M, Safgren SL, Kuffel M, Jakesz R, Rudas M, Greil R, Dietze O, Lang A, Offner F, Reynolds CA, Weinshilboum RM, Ames MM, Ingle JN

Clinical Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/23213055

Efficacy of tamoxifen ± aminoglutethimide in normal weight and overweight postmenopausal patients with hormone receptor-positive breast cancer: an analysis of 1509 patients of the ABCSG-06 trial

Pfeiler G, Stöger H, Dubsky P, Mlineritsch B, Singer C, Balic M, Fitzal F, Moik M, Kwasny W, Selim U, Renner K, Ploner F, Steger G, Seifert M, Hofbauer F, Sandbichler P, Samonigg H, Jakesz R, Greil R, Fesl C, Gnant M

British Journal of Cancer

https://www.ncbi.nlm.nih.gov/pubmed/23511562

Impact of body mass index on estradiol depletion by aromatase inhibitors in postmenopausal women with early breast cancer

Pfeiler G, Königsberg R, Hadji P, Fitzal F, Maroske M, Dressel-Ban G, Zellinger J, Exner R, Seifert M, Singer C, Gnant M, Dubsky P

British Journal of Cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777005/

The predictive impact of body mass index on the efficacy of extended adjuvant endocrine treatment with anastrozole in postmenopausal patients with breast cancer: an analysis of the randomised ABCSG-6a trial

Gnant M, Pfeiler G, Stöger H, Mlineritsch B, Fitzal F, Balic M, Kwasny W, Seifert M, Stierer M, Dubsky P, Greil R, Steger G, Samonigg H, Fesl C, Jakesz R on behalf of the Austrian Breast and Colorectal Cancer Study Group

British Journal of Cancer

https://www.ncbi.nlm.nih.gov/pubmed/23868011

Preparing for Prospective Clinical Trials: A National Initiative of an Excellence Registry for Consecutive Pancreatic Cancer Resections

Gangl O, Sahora K, Kornprat P, Margreiter C, Primavesi F, Bareck E, Schindl M, Längle F, Öfner D, Mischinger H-J, Pratschke J, Gnant M, Függer R

World Journal of Surgery

https://www.ncbi.nlm.nih.gov/pubmed/24121365

The EndoPredict score provides prognostic information on late distant metastases in ERþ/HER2 breast cancer patients

Dubsky P, Brase J C, Jakesz R, Rudas M, Singer C F, Greil R, Dietze O, Luisser I, Klug E, Sedivy R, Bachner M, Mayr D, Schmidt M, Gehrmann M C, Petry C, Weber K E, Fisch K, Kronenwett R, Gnant M, Filipits M on behalf of the Austrian Breast and Colorectal Cancer Study Group (ABCSG)

British Journal of Cancer

https://www.ncbi.nlm.nih.gov/pubmed/24157828

Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1

Heitzer E, Artl M, Filipits M, Resel M, Graf R, Weißenbacher B, Lax S, Gnant M, Wrba F, Greil R, Dietze O, Hofbauer F, Böhm G, Höfler G, Samonigg H, Schaberl-Moser R, Balic M and Dandachi N

Modern Pathology

https://www.ncbi.nlm.nih.gov/pubmed/24309322

Epirubicin and docetaxel with or without capecitabine as neoadjuvant treatment for early breast cancer: final results of a randomized phase III study (ABCSG-24)

Steger G, Greil R, Lang A, Rudas M, Fitzal F, Mlineritsch B, Hartmann B, Bartsch R, Melbinger E, Hubalek M, Stoeger H, Dubsky P, Ressler S, Petzer A, Singer C, Muss C, Jakesz R, Gampenrieder S, Zielinski C, Fesl C, Gnant M on behalf of the Austrian Breast and Colorectal Study Group (ABCSG)

Annals of Oncology

https://www.ncbi.nlm.nih.gov/pubmed/24347519

Predicting distant recurrence in receptor-positive breast cancer patients with limited clinicopathological risk: using the PAM50 Risk of Recurrence score in 1478 postmenopausal patients of the ABCSG-8 trial treated with adjuvant endocrine therapy alone

Gnant M, Filipits M, Greil R, Stoeger H, Rudas M, Bago-Horvath Z, Mlinertisch B, Kwasny W, Knauer M, Singer C, Jakesz R, Dubsky P, Fitzal F, Bartsch R, Steger G, Balic M, Ressler S, Cowens J, Storhoff J, Ferree S, Schaper C, Liu S, Fesl C, Nielsen T, on behalf of the Austrian Breast and Colorectal Cancer Study Group (ABCSG)

Annals of Oncology

https://www.ncbi.nlm.nih.gov/pubmed/24347518

The EndoPredict score provides prognostic information on late distant metastases in ERþ/HER2 breast cancer patients

Dubsky P, Brase J C, Jakesz R, Rudas M, Singer C F, Greil R, Dietze O, Luisser I, Klug E, Sedivy R, Bachner M, Mayr D, Schmidt M, Gehrmann M C, Petry C, Weber K E, Fisch K, Kronenwett R, Gnant M, Filipits M on behalf of the Austrian Breast and Colorectal Cancer

British Journal of Cancer (2013)
Advance online publication 24 October 2013

Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1

Heitzer E, Artl M, Filipits M, Resel M, Graf R, Weißenbacher B, Lax S, Gnant M, Wrba F, Greil R, Dietze O, Hofbauer F, Böhm G, Höfler G, Samonigg H, Schaberl-Moser R, Balic M and Dandachi N

Modern Pathology 1-10, 2013.

EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer

Dubsky P, Filipits M, Jakesz R, Rudas M, Singer CF, Greil R, Dietze O, Luisser I, Klug E, Sedivy R, Bachner M, Mayr D, Schmidt M, Gehrmann MC, Petry C, Weber KE, Kronenwett R, Brase JC, Gnant M on behalf of the Austrian Breast and Colorectal Cancer Study Group (ABCSG)..

Ann Oncol 24, 640-647, 2013.

Cytochrome P450 2D6 poor metabolizer phenotype is associated with worse outcomes in women receiving tamoxifen: results from the Austrian Breast and Colorectal Study 8

Goetz MP, Suman VJ, Ames MM, Gnant M, Filipits M, Hoskin TL, Safgren SL, Kuffel M, Jakesz R, Rudas M, Greil R, Dietze O, Lang A, Offner F, Reynolds CA, Weinshilboum RM, Ingle JN.

Clin Cancer Res 107, 1978-1986, 2013.

Ovarian function suppression and fulvestrant as endocrine therapy in premenopausal women with metastatic breast cancer

Bartsch R, Bago-Horvath Z, Berghoff A, DeVries C, Pluschnig U, Dubsky P, Rudas M, Mader RM, Rottenfusser A, Fitzal F, Gnant M, Zielinski C, Steger G

European Journal of Cancer

https://www.ncbi.nlm.nih.gov/pubmed/22459763

EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer

Dubsky P, Filipits M, Jakesz R, Rudas M, Singer C F, Greil R, Dietze O, Luisser I, Klug E, Sedivy R, Bachner M, Mayr D, Schmidt M, Gehrmann M C, Petry C, Weber K E, Kronenwett R, Brase J C, Gnant M

Annals of Oncology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574544/

Tamoxifen and Anastrozole As a Sequencing Strategy: A Randomized Controlled Trial in Postmenopausal Patients With Endocrine-Responsive Early Breast Cancer From the Austrian Breast and Colorectal Cancer Study Group

Dubsky P, Jakesz R, Mlineritsch B, Pöstlberger S, Samonigg H, Kwasny W, Tausch C, Stöger H, Haider K, Fitzal F, Singer C, Stierer M, Sevelda P, Luschin-Ebengreuth G, Taucher S, Rudas M, Bartsch R, Steger G, Greil R, Filipcic L, Gnant M

Journal of Clinical Oncology

https://www.ncbi.nlm.nih.gov/pubmed/22271481

Neoadjuvant Chemotherapy Increases the Rate of Breast Conservation in Lobular-Type Breast Cancer Patients

Fitzal F, Mittlboeck M, Steger G, Bartsch R, Rudas M, Dubsky F, Riedl O, Jakesz R, Gnant M

Annals of Surgical Oncology

https://www.ncbi.nlm.nih.gov/pubmed/21743980

The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis

Hadji P, Coleman R, Gnant M, Green J

Annals of Oncology Advance Access

https://www.ncbi.nlm.nih.gov/pubmed/22730099

Results of the First Austrian Multidisciplinary Expert Panel on Controversies in Local Treatment of Breast Cancer

Knauer M, Gnant M, Fitzal F

Breast Care

https://www.ncbi.nlm.nih.gov/pubmed/22553475

Preoperative treatment with capecitabine, bevacizumab and radiotherapy for primary locally advanced rectal cancer – a two stage phase II clinical trial

Resch G, de Vries A, Öfner D, Eisterer W, Rabl H, Jagoditsch M, Gnant M, Thaler J

Radiotherapy and Oncology

https://www.ncbi.nlm.nih.gov/pubmed/21741716

Podoplanin-expressing cancer-associated fibroblasts are associated with poor prognosis in invasive breast cancer

Schoppmann SF, Berghoff A, Dinhof C, Jakesz R, Gnant M, Dubsky P, Jesch B, Heinzl H, Birner P

Breast Cancer Research and Treatment

https://www.ncbi.nlm.nih.gov/pubmed/22350732

Prognostic Value of Number of Removed Lymph Nodes, Number of Involved Lymph Nodes, and Lymph Node Ratio in 7502 Breast Cancer Patients Enrolled onto Trials of the Austrian Breast and Colorectal Cancer Study Group (ABCSG)

Tausch C, Taucher S, Dubsky P, Seifer M, Reitsamer R, Kwasny W, Jakesz R, Fitzal F, Filipcic L, Fridrik M, Greil R, Gnant M

Annals of Surgical Oncology

https://www.ncbi.nlm.nih.gov/pubmed/22207051

Response to: Dual inhibition of HER2 in breast cancer treatment

Gnant M, Steger G

The Lancet

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60068-3/fulltext

Direct and indirect anticancer activity of bisphosphonates: A brief review of published literature

Gnant M, Philippe Clézardin

Cancer Treatment Reviews

https://www.ncbi.nlm.nih.gov/pubmed/21983264

Adjuvant Sequencing of Tamoxifen and Anastrozole Is Superior to Tamoxifen Alone in Postmenopausal Women with Low Proliferating Breast Cancer

Bago-Horvath Z, Rudas M, Dubsky P

American Association for Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/21998336

A new Molecular Predictor of Distant Recurrence in ER-positive, HER2-negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors

Filipits M, Rudas M, Jakesz R, Dubsky P, Fitzal F, Singer Ch, Dietze O, Greil R, Jelen A, Sevelda P, Freibauer Ch, Müller V, Jänicke F, Schmidt M, Kölbl H, Rody A, Kaufmann M, Schroth W, Brauch H, Schwab M, Fritz P, Weber K, Feder I, Hennig G, Kronenwett R, Gehrmann M, Gnant M

American Association for Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/21807638

62-Month follow-up of ABCSG-12: Adjuvant endocrine therapy, alone or in combination with zoledronic acid, in premenopausal patients with endocrine-responsive early breast cancer

Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Poestlberger S, Steger G, Jakesz R, Singer C, Eidtmann H, Greil R

Bone

https://www.researchgate.net/publication/

Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial

Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Heck D, Menzel Ch, Jakesz R, Seifert M, Hubalek M, Pristauz G, Bauernhofer T, Eidtmann H, Eiermann W, Steger G, Kwasny W, Dubsky P, Hochreiner G, Forsthuber EP, Fesl Ch, Greil R

The Lancet Oncology

https://www.ncbi.nlm.nih.gov/pubmed/21641868

Zoledronic acid in breast cancer: latest findings and interpretations

Gnant M

Therapeutic Advances in Medical Oncology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210470/

Preoperative oxaliplatin, capecitabine, and external beam radiotherapy in patients with newly diagnosed, primary operable, cT3NxM0, low rectal cancer a phase II study

Öfner D, DeVries AF, Schaberl-Moser R, Greil R, Rabl H, Tschmelitsch J, Zitt M, Kapp KS, Fastner G, Keil F, Eisterer W, Jäger R, Offner F, Gnant M, Thaler J

Strahlentherapie und Onkologie

https://www.researchgate.net/publication/

Impact of Body Mass Index on the Efficacy of Endocrine Therapy in Premenopausal Patients with Breast Cancer: An Analysis of the Prospective ABCSG-12 Trial

Pfeiler G, Königsberg R, Fesl Ch, Mlineritsch B, Stoeger H, Singer CF, Pöstlberger S, Steger G, Seifert m, Dubsky P, Taucher S, Samonigg H, Bjelic-Radisic V, Greil R, Marth Ch, Gnant M

Journal of Clinical Oncology

https://ascopubs.org/doi/10.1200/JCO.2010.33.2585

Zoledronic acid for adjuvant use in patients with breast cancer

Ressler S, Mlineritsch B, Greil R

Expert review of anticancer therapy

https://www.ncbi.nlm.nih.gov/pubmed/21417849

Sentinel Node Biopsy After Primary Chemotherapy in Breast Cancer: A Note of Caution from Results of ABCSG-14

Tausch C, Steger G, Haid A, Jakesz R, Fridrik M, Reitsamer R, Pöstlberger S, Lang A, Gnant M, Greil R

The Breast Journal

https://www.ncbi.nlm.nih.gov/pubmed/21450019

Adjuvant bisphosphonates – an option with low estrogen?

Gnant M

Nature Reviews

https://www.nature.com/articles/nrclinonc.2011.170

The benefit of adjuvant sequencing of tamoxifen and anastrozole over tamoxifen alone is confined in women with low proliferating endocrine-responsive breast cancer: Results from 1,587 centrally reviewed Ki67-labelling determinations in the Austrian Breast and Colorectal Cancer Study Group Trial 8

Bago-Horvath Z, Rudas M, Dubsky P, Jakesz R, Singer C, Dietze O, Greil R, Jelen A, Böhm G, Jasarevic Z, Haid A, Gruber C, Pöstlberger S, Filipits M, Gnant M.

Clin Cancer Res 17, 7828-7834, 2011.

A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors

Filipits M, Rudas M, Jakesz R, Dubsky P, Fitzal F, Singer CF, Dietze O, Greil R, Jelen A, Sevelda P, Freibauer C, Müller V, Jänicke F, Schmidt M, Kölbl H, Rody A, Kaufmann M, Schroth W, Schwab M, Brauch H, Fritz P, Weber KE, Feder IS, Hennig G, Kronenwett R, Gehrmann M, Gnant M.

Clin Cancer Res 17, 6012-6020, 2011.