ABCSG C08 / EXERCISE
Status: Treatment Phase & Follow-up
A randomized, phase III trial of endurance exercise following adjuvant chemotherapy for colorectal cancer
| Coordinating Investigator: | Gudrun Piringer (Linz) |
| Start of study: | 11/2018 (national) |
| Sample size: | 100 |
| Sponsor (Österreich): | ABCSG |
Description and status:
The ABCSG C08 / EXERCISE II study is a randomized, two-arm, multicenter trial to investigate the efficacy of endurance exercise following adjuvant chemotherapy in patients with colorectal cancer. This study is sponsored and coordinated by ABCSG, and includes 8 Austrian sites, in Vienna, Linz, Graz, Salzburg, Steyr, Kufstein, Ried, Braunau, and Wels. By the end of 2024, when enrollment was closed, a total of 91 patients had been registered.
The main aim is to reduce relapse rates and improve the quality of life by an increase of the physical activity of a patient. Participants within the training group receive individually supervised training based on regularly performed ergometries. They are encouraged to complete the endurance training three times a week for an intended period of 12 months. After a slow build-up phase during the first months, the time required for training is estimated with three hours per week. The results are compared to patients doing only their usual physical activities.
In addition to the usual follow-up care after a colorectal cancer treatment, a variety of other parameters such as increased physical performance, quality of life, metabolic parameters or molecular markers are assessed in the course of the study. The follow-up phase will be conducted over a period of 36 months.
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