ABCSG-Publications (peer reviewed) 2022-2021
The publication of study results is an essential mandate of the ABCSG. Therapy improvements can only be made accessible to the entire medical-scientific community through publications. As a result, our knowledge of cancer is continuously increasing and the chances of winning the battle against it increase.
The publications listed here are the result of many years of successful work by the ABCSG.
Long-Term Outcomes of Adjuvant Denosumab in Breast Cancer
Michael Gnant, M.D.1,2, Sophie Frantal, M.Sc.2, Georg Pfeiler, M.D.3, Guenther G. Steger, M.D.,4, Daniel Egle, M.D.5, Richard Greil, M.D.6, Florian Fitzal, M.D.7, Viktor Wette, M.D.8, Marija Balic, M.D.9, Ferdinand Haslbauer, M.D.10, Elisabeth Melbinger-Zeinitzer, M.D.11, Vesna Bjelic-Radisic, M.D.12,13, Silvia Artner-Matuschek, M.D.14, Franz Kainberger, M.D.15, Magdalena Ritter, M.D.5, Gabriel Rinnerthaler, M.D.6, Paul Sevelda, M.D.16, Jonas Bergh, M.D.17, Stephanie Kacerovsky-Strobl, M.D.7,18, Christoph Suppan, M.D.9, Christine Brunner, M.D.5, Christine Deutschmann, M.D.3, Simon P. Gampenrieder, M.D.6, Hannes Fohler, M.V.M.2, Raimund Jakesz, M.D.7, Christian Fesl, Ph.D.2, and Christian Singer, M.D.3for the Austrian Breast & Colorectal Cancer Study Group*
NJEM Evidence, November 2022, Vol.1 No.12, DOI: https://doi.org/10.1056/EVIDoa2200162
Estrogen Receptor Alpha Gene Amplification Is an Independent Predictor of Long-Term Outcome in Postmenopausal Patients with Endocrine-Responsive Early Breast Cancer
Christian F. Singer, for the ABCSG; Frederik Holst, Stefan Steurer , Eike C. Burandt , Sigurd F. Lax, Raimund Jakesz , Margaretha Rudas , Herbert Stoger , Richard Greil ,for the ABCSG; Guido Sauter, Martin Filipits, for the ABCSG, Ronald Simon, and Michael Gnant; for the ABCSG
Clinical Cancer Research, ePub August 2022, DOI: 10.1158/1078-0432.CCR-21-4328.
https://aacrjournals.org/
Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy.
Weber WP, Shaw J, Pusic A, Wyld L, Morrow M, King T, Mátrai Z, Heil J, Fitzal F, Potter S, Rubio IT, Cardoso MJ, Gentilini OD, Galimberti V, Sacchini V, Rutgers EJT, Benson J, Allweis TM, Haug M, Paulinelli RR, Kovacs T, Harder Y, Gulluoglu BM, Gonzalez E, Faridi A, Elder E, Dubsky P, Blohmer JU, Bjelic-Radisic V, Barry M, Hay SD, Bowles K, French J, Reitsamer R, Koller R, Schrenk P, Kauer-Dorner D, Biazus J, Brenelli F, Letzkus J, Saccilotto R, Joukainen S, Kauhanen S, Karhunen-Enckell U, Hoffmann J, Kneser U, Kühn T, Kontos M, Tampaki EC, Carmon M, Hadar T, Catanuto G, Garcia-Etienne CA, Koppert L, Gouveia PF, Lagergren J, Svensjö T, Maggi N, Kappos EA, Schwab FD, Castrezana L, Steffens D, Krol J, Tausch C, Günthert A, Knauer M, Katapodi MC, Bucher S, Hauser N, Kurzeder C, Mucklow R, Tsoutsou PG, Sezer A, Çakmak GK, Karanlik H, Fairbrother P, Romics L, Montagna G, Urban C, Walker M, Formenti SC, Gruber G, Zimmermann F, Zwahlen DR, Kuemmel S, El-Tamer M, Vrancken Peeters MJ, Kaidar-Person O, Gnant M, Poortmans P, de Boniface J.
The Breast, March 2022, DOI: 10.1016/j.breast.2022.03.008.
https://pubmed.ncbi.nlm.nih.gov/35366506/
Effect of concomitant statin treatment in postmenopausal patients with hormone receptor-positive early-stage breast cancer receiving adjuvant denosumab or placebo: a post hoc analysis of ABCSG-18.
Minichsdorfer C, Fuereder T, Leutner M, Singer CF, Kacerovsky-Strobl S, Egle D, Greil R, Balic M, Fitzal F, Pfeiler G, Frantal S, Bartsch R, Gnant M.
ESMO Open, March 2022. DOI: 10.1016/j.esmoop.2022.100426.
https://pubmed.ncbi.nlm.nih.gov/35334418/
Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)
The Lancet Oncology, March 2022, DOI: 10.1016/S1470-2045(21)00758-0
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00758-0/fulltext
Safety of adjuvant CDK4/6 inhibitors during the COVID-19 pandemic
Georg Pfeiler, Angela DeMichele, Amylou C. Dueck, Christian Fesl, Michael Gnant, Erica L. Mayer
The Lancet Oncology, 2 February 2022; DOI:
https://doi.org/10.1016/S1470-2045(21)00708-7
Treatment Exposure and Discontinuation in the PALbociclib CoLlaborative Adjuvant Study of Palbociclib With Adjuvant Endocrine Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer (PALLAS/AFT-05/ABCSG-42/BIG-14-03)
Mayer E L, Fesl C, Hlauschek D, Garcia-Estevez L, Burstein H J, Zdenkowski N, Wette V, Miller K D, Balic M, Mayer I A, Cameron D, Winer E P, Ponce Lorenzo J J, Lake D, Pristauz-Telsnigg G, Haddad T C, Shepherd L, Iwata H, Goetz M, Cardoso F, Traina TA, Sabanathan D, Breitenstein U, Ackerl K, Metzger Filho O, Zehetner K, Solomon K, El-Abed S, Theall K P, Lu D R, Dueck A, Gnant M, DeMichele A.
Journal of Clinical Oncology, 07 January 2022, DOI: 10.1200/JCO.21.01918
https://pubmed.ncbi.nlm.nih.gov/34995105/
Persistence of ctDNA in breast cancer patients during neoadjuvant treatment is a significant predictor of poor tumour response
Qing Zhou, Simon P. Gampenrieder, Sophie Frantal ,Gabriel Rinnerthaler, Christian F. Singer , Daniel Egle, Georg Pfeiler, Rupert Bartsch, Viktor Wette, Angelika Pichler , Edgar Petru, Peter C. Dubsky , Zsuzsanna Bago-Horvath, Christian Fesl , Margaretha Rudas , Anders Ståhlberg, Ricarda Graf , Sabrina Weber, Nadia Dandachi, Martin Filipits , Michael Gnant , Marija Balic, Ellen Heitzer on behalf of the 7 ABCSG
American Association for Cancer Research, December 3, 2021; DOI: 10.1158/1078-0432
https://clincancerres.aacrjournals.org/content/early/2021/12/02/1078-0432.CCR-21-3231
Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/ original reports AFT-05/BIG-14-03)
Michael Gnant, MD; Amylou C. Dueck, PhD; Sophie Frantal, MSc; Miguel Martin, MD ; Hal J. Burstein, MD ; Richard Greil, MD; Peter Fox, MBBS; Antonio C. Wolff, MD; Arlene Chan, MMed; Eric P. Winer, MD; Georg Pfeiler, MD; Kathy D. Miller, MD; Marco Colleoni, MD; Jennifer M. Suga, MD; Gabor Rubovsky, PhD; Judith M. Bliss, MSc; Ingrid A. Mayer, MD; Christian F. Singer, MD; Zbigniew Nowecki, MD; Olwen Hahn, MD; Jacqui Thomson, MBBS; Norman Wolmark, MD; Kepa Amillano, MD; Hope S. Rugo, MD; Guenther G. Steger, MD; Blanca Hernando Fern ´andez de Ar ´anguiz, MD 5,24 ; Tufia C. Haddad, MD 25 ; Antonia Perell ´o, MD 26 ; Meritxell Bellet, MD; Hannes Fohler, MVM; Otto Metzger Filho, MD; Anita Jallitsch-Halper, PhD 2 ; Kadine Solomon, BA; C´eline Schurmans, MSc; Kathy P. Theall, MD; Dongrui R. Lu, MS; Kathleen Tenner, MSc; Christian Fesl, PhD; Angela DeMichele, MD; and Erica L. Mayer, MD, MPH on behalf of the PALLAS groups and investigators
Journal of Clinical Oncology, 07 Dezember 2021, DOI: 10.1200/JCO.21.02554
https://ascopubs.org/doi/abs/10.1200/JCO.21.02554
The CIRCULATE Trial: Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation (AIO-KRK-0217)
Gunnar Folprecht, Anke Reinacher-Schick, Jürgen Weitz, Celine Lugnier, Anna-Lena Kraeft, Sarah Wisser, Daniela E. Aust, Lukas Weiss, Nikolas von Bubnoff, Michael Kramer, Christian Thiede, Andrea Tannapfel
Journal Clinical Colorectal Cancer, 9 November 2021, DOI: 10.1016/j.clcc.2021.09.005
https://pubmed.ncbi.nlm.nih.gov/34772609/
Continuous vs intermittent extended adjuvant letrozole for breast cancer: Final results of randomized phase 3 SOLE (Study of Letrozole Extension) and SOLE Estrogen Substudy.
Jerusalem G, Farah S, Courtois A, Chirgwin J, Aebi S, Karlsson P, Neven P, Hitre E, Graas MP, Simoncini E, Abdi E, Kamby C, Thompson A, Loibl S, Gavilá J, Kuroi K, Marth C, Müller B, O’Reilly S, Gombos A, Ruhstaller T, Burstein HJ, Rabaglio M, Ruepp B, Ribi K, Viale G, Gelber RD, Coates AS, Loi S, Goldhirsch A, Regan MM, Colleoni M. on behalf of the SOLE Investigators.
Annals of Oncology, October 2021; 32(10):1256-1266. DOI: 10.1016/j.annonc.2021.07.017.
https://pubmed.ncbi.nlm.nih.gov/34384882/
ABCSG 48 / POSITIVE: Who are the women who enrolled in the POSITIVE trial: A global study to support young hormone receptor positive breast cancer survivors desiring pregnancy
Ann H. Partridge, Samuel M. Niman, Monica Ruggeri Fedro A. Peccatori, Hatem A. Azim Jr., Marco Colleoni, Cristina Saura, Chikako Shimizu, Anna Barbro Sætersdal, Judith R. Kroep, Audrey Mailliez, Ellen Warner, Virginia F. Borges, Frédéric Amant, Andrea Gombos, Akemi Kataoka, Christine Rousset-Jablonski, Simona Borstnar, Junko Takei, Jeong Eon Lee, Janice M. Walshe, Manuel Ruíz Borrego, Halle CF. Moore, Christobel Saunders, Fatima Cardoso, Snezana Susnjar, Vesna Bjelic-Radisic, Karen L. Smith, Martine Piccart, Larissa A. Korde, Aron Goldhirsch, Richard D. Gelber, Olivia Pagani
The Beast, August 2021, DOI:
https://doi.org/10.1016/j.breast.2021.07.021
Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer
Michael Gnant, Florian Fitzal, Gabriel Rinnerthaler, Guenther G. Steger, Sigrun Greil-Ressler, Marija Balic, Dietmar Heck, Raimund Jakesz, Josef Thaler, Daniel Egle, Diether Manfreda, Vesna Bjelic-Radisic, Ursula Wieder, Christian F. Singer, Elisabeth Melbinger-Zeinitzer, Ferdinand Haslbauer, Paul Sevelda, Harald Trapl, Viktor Wette, Kerstin Wimmer, Simon P. Gampenrieder, Rupert Bartsch, Stephanie Kacerovsky-Strobl, Christoph Suppan, Christine Brunner, Christine Deutschmann, Lidija Soelkner, Christian Fesl, Richard Greil, on behalf of the Austrian Breast and Colorectal Cancer Study Group
N Engl J Med, 29 July 2021;385:395-405. DOI: 10.1056/NEJMoa2104162
https://www.nejm.org
Genomic and transcriptomic analyses of breast cancer primaries and matched metastases in AURORA, the Breast International Group (BIG) molecular screening initiative
Philippe Aftimos, Mafalda Oliveira, Alexandre Irrthum, Debora Fumagalli, Christos Sotiriou, Einav Nili Gal-Yam, Mark E Robson, Justin Ndozeng, Angelo Di Leo, Eva M Ciruelos, Evandro de Azambuja, Giuseppe Viale, Elsemieke D Scheepers, Giuseppe Curigliano, Judith M Bliss, Jorge S Reis-Filho, Marco Colleoni, Marija Balic, Fatima Cardoso, Joan Albanell, Caroline Duhem, Sandrine Marreaud, Dario Romagnoli, Beatriz Rojas, Andrea Gombos, Hans Wildiers, Angel GUERRERO-ZOTANO, Peter Hall, Andrea Bonetti, Karolina Fs Larsson, Martina Degiorgis, Silvia Khodaverdi, Richard Greil, Asgerdur Sverrisdottir, Marta Paoli, Ethel Seyll, Sybille Loibl, Barbro Linderholm, Gabriele Zoppoli, Nancy E Davidson, Oskar Th Johannsson, Philippe L Bedard, Sherene Loi, Susan Knox, David A Cameron, Nadia Harbeck, Maite Lasa Montoya, Mariana Brandão, Andrea Vingiani, Carmela Caballero, Florentine S Hilbers, Lucy R Yates, Matteo Benelli, David Venet and Martine J Piccart
Cancer Discovery June 28, 2021, doi: 10.1158/2159-8290.CD-20-1647
https://cancerdiscovery.aacrjournals.org/content/early/2021/06/24/2159-8290.CD-20-1647
Palbociclib for Residual High-Risk Invasive HR-Positive and HER2-Negative Early Breast Cancer—The Penelope-B Trial
Sibylle Loibl, Frederik Marmé, Miguel Martin, Michael Untch, Hervé Bonnefoi, Sung-Bae Kim, Harry Bear, Nicole McCarthy, Mireia Melé Olivé, Karen Gelmon, José García-Sáenz, Catherine M. Kelly, Toralf Reimer, Masakazu Toi, Hope S. Rugo, Carsten Denkert, Michael Gnant, Andreas Makris, Maria Koehler, Cynthia Huang-Bartelett, Maria Jose Lechuga Frean, Marco Colleoni, Gustavo Werutsky, Sabine Seiler, Nicole Burchardi, Valentina Nekljudova, and Gunter von Minckwitz
Journal of Clinical Oncology, 2021 May 10;39(14):1518-1530. doi: 10.1200/JCO.20.03639. Epub 2021 Apr 1.
https://ascopubs.org/doi/10.1200/JCO.20.03639
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer
Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators.
N Engl J Med. June 3 2021 doi: 10.1056/NEJMoa2105215. Epub ahead of print. PMID: 34081848.
https://www.nejm.org/doi/full/10.1056/NEJMoa2105215
Conventional versus reverse sequence of neoadjuvant epirubicin/cyclophosphamide and docetaxel: sequencing results from ABCSG-34
Rupert Bartsch, Christian F. Singer , Georg Pfeiler, Michael Hubalek, Herbert Stoeger, Angelika Pichler, Edgar Petru, Vesna Bjelic-Radisic, Richard Greil8, Margaretha Rudas, Tea Maria Muy-Kheng, Viktor Wette, Andreas L. Petzer, Paul Sevelda, Daniel Egle, Peter C. Dubsky, Martin Filipits, Florian Fitzal, Ruth Exner , Raimund Jakesz, Marija Balic,Christoph Tinchon, Zsuzsanna Bago-Horvath, Sophie Frantal, Michael Gnant and for the Austrian Breast and Colorectal Cancer Study Group
British Journal of Cancer, March 2021
https://doi.org/10.1038/s41416-021-01284-2
A clinical validation study of MammaPrint in hormone receptor-positive breast cancer from the Austrian Breast and Colorectal Cancer Study Group 8 (ABCSG-8) biomarker cohort
P.Dubsky, L.Van’t Veer, M.Gnant, M.Rudas, Z.Bago-Horvath, R.Greil, E.Lujinovic, J.Buresch, G.Rinnerthaler, W.Hulla, F.Moinfar, D.Egle, W.Herz, C.Dreezen, S.Frantal, M.Filipits
ESMO Open, Feb 2021
https://doi.org/10.1016/j.esmoop.2020.100006
Palbociclib with adjuvant endocrine therapy in early breast cancer (PALLAS): interim analysis of a multicentre, open-label, randomised, phase 3 study
Erica L Mayer, Amylou C Dueck, Miguel Martin, Gabor Rubovszky, Harold J Burstein, Meritxell Bellet-Ezquerra, Kathy D Miller, Nicholas Zdenkowski, Eric P Winer, Georg Pfeiler, Matthew Goetz, Manuel Ruiz-Borrego, Daniel Anderson, Zbigniew Nowecki, Sibylle Loibl, Stacy Moulder, Alistair Ring, Florian Fitzal, Tiffany Traina, Arlene Chan, Hope S Rugo, Julie Lemieux, Fernando Henao, Alan Lyss, Silvia Antolin Novoa, Antonio C Wolff, Marcus Vetter, Daniel Egle, Patrick G Morris, Eleftherios P Mamounas, Miguel J Gil-Gil, Aleix Prat, Hannes Fohler, Otto Metzger Filho, Magdalena Schwarz, Carter DuFrane, Debora Fumagalli, Kathy Puyana Theall, Dongrui Ray Lu, Cynthia Huang Bartlett, Maria Koehler, Christian Fesl, Angela DeMichele, Michael Gnant,
The Lancet Oncology, Jan 2021,
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30642-2/fulltext
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