{"id":39592,"date":"2025-08-27T06:02:29","date_gmt":"2025-08-27T04:02:29","guid":{"rendered":"https:\/\/www.abcsg.org\/?page_id=39592"},"modified":"2026-08-20T16:10:23","modified_gmt":"2026-08-20T14:10:23","slug":"abcsg-63-erika","status":"publish","type":"page","link":"https:\/\/www.abcsg.org\/en\/abcsg-studien\/studies-in-treatment-phase-follow-up\/abcsg-63-erika\/","title":{"rendered":"ABCSG 63 \/ ERIKA"},"content":{"rendered":"<p>An open-label, two-arm, randomized, phase II study of elacestrant plus ribociclib vs. AI (plus GnRH agonist in pre-\/perimenopausal women and men) plus ribociclib as neoadjuvant therapy for endocrine-responsive HER2-negative early breast cancer<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Coordinating Investigator:<\/strong><\/td>\n<td>Christian Singer, Wien; Michael Gnant, Wien<\/td>\n<\/tr>\n<tr>\n<td><strong>Study of start:<\/strong><\/td>\n<td>09\/2025<\/td>\n<\/tr>\n<tr>\n<td><strong>Sample size:<\/strong><\/td>\n<td>120 (\u00d6sterreich, Deutschland)<\/td>\n<\/tr>\n<tr>\n<td><strong>Sponsor:<\/strong><\/td>\n<td>ABCSG<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Description and status:<\/h3>\n<p>ABCSG 63 \/ ERIKA is a randomised, two-arm, open-label phase II study involving 10 centers in Austria and 8 centers in Germany. A total of 120 participants were enrolled, and recruitment was completed as early as July 2026 (instead of September 2026 as originally planned) thanks to the excellent cooperation with the participating trial centres. Participating patients receive elacestrant and ribociclib in treatment arm A, and an aromatase inhibitor (in combination with GnRH agonists in pre- and perimenopausal women and men) and ribociclib in treatment arm B, for the neoadjuvant treatment of ER-positive, HER2-negative early-stage breast cancer.<\/p>\n<p>The primary objective is to evaluate the superiority of the study treatment when measured by modified PEPI score at the time of surgery.<\/p>\n<p>The study is scheduled to conclude in February 2027 (i.e., the final follow-up visit for the last patient).\u00a0<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An open-label, two-arm, randomized, phase II study of elacestrant plus ribociclib vs. AI (plus GnRH agonist in pre-\/perimenopausal women and men) plus ribociclib as neoadjuvant therapy for endocrine-responsive HER2-negative early breast cancer Coordinating Investigator: Christian Singer, Wien; Michael Gnant, Wien Study of start: 09\/2025 Sample size: 120 (\u00d6sterreich, Deutschland) Sponsor: ABCSG Description and status: ABCSG [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":32914,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-onepagestudy.php","meta":{"_acf_changed":false,"footnotes":"","_members_access_role":[],"_members_access_error":""},"tags":[],"class_list":["post-39592","page","type-page","status-publish","hentry"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2027-02-20 17:06:33","action":"delete","newStatus":"draft","terms":[],"taxonomy":"translation_priority","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/39592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/comments?post=39592"}],"version-history":[{"count":5,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/39592\/revisions"}],"predecessor-version":[{"id":42056,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/39592\/revisions\/42056"}],"up":[{"embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/32914"}],"wp:attachment":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/media?parent=39592"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/tags?post=39592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}