{"id":29752,"date":"2020-05-27T06:26:47","date_gmt":"2020-05-27T04:26:47","guid":{"rendered":"https:\/\/www.abcsg.org\/?page_id=29752"},"modified":"2024-04-09T06:33:09","modified_gmt":"2024-04-09T04:33:09","slug":"abcsg-18-za-overview","status":"publish","type":"page","link":"https:\/\/www.abcsg.org\/en\/abcsg-studies-archive\/abcsg-18-and-zoledronic-acid-substudy\/abcsg-18-za-overview\/","title":{"rendered":"ABCSG 18 ZA Overview"},"content":{"rendered":"<p>A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study to Determine the Treatment Effect of Denosumab in Subjects With Non-Metastatic Breast Cancer Receiving Aromatase Inhibitor Therapy\/ Zoledronic Acid (ZA) Substudy<\/p>\n<p>ABCSG 18 ZA was developed as an additional protocol to assess the effects of a single intravenous ZA administration on bone density, fracture incidence, and bone turnover markers (CTX and osteocalcin) in a subset of ABCSG 18 patients<\/p>\n<table class=\"studienmeta-public\">\n<tbody>\n<tr>\n<td>Start:<\/td>\n<td>02\/2020<\/td>\n<\/tr>\n<tr>\n<td>Coordinating Investigator:<\/td>\n<td>Michael Gnant; Vienna<\/td>\n<\/tr>\n<tr>\n<td>Sample size:<\/td>\n<td>ABCSG 18: 3400 (Austria + Sweden); <br \/>\nABCSG 18 ZA: planned in a subset of patients<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study to Determine the Treatment Effect of Denosumab in Subjects With Non-Metastatic Breast Cancer Receiving Aromatase Inhibitor Therapy\/ Zoledronic Acid (ZA) Substudy ABCSG 18 ZA was developed as an additional protocol to assess the effects of a single intravenous ZA administration on bone density, fracture incidence, and bone [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":35541,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"page-einzel-studie-intern.php","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-29752","page","type-page","status-publish","hentry"],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-10-14 10:46:29","action":"delete","newStatus":"draft","terms":[],"taxonomy":"translation_priority","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/29752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/comments?post=29752"}],"version-history":[{"count":1,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/29752\/revisions"}],"predecessor-version":[{"id":29753,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/29752\/revisions\/29753"}],"up":[{"embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/pages\/35541"}],"wp:attachment":[{"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/media?parent=29752"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abcsg.org\/en\/wp-json\/wp\/v2\/tags?post=29752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}